Insights into all aspects of drug discovery, design and development

How to ensure your high throughput screening program is a resource-efficient hit

High throughput screening (HTS) has long been an important first step in the search for new drug molecules. Here, the goal is to identify high-quality hits that can be easily optimized into lead compounds and ultimately, safe and effective medicines. In recent years HTS has become something of a ...

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Adopt a considered screening strategy for your hit identification campaign

Developing robust and reliable high-throughput screening assays High-throughput screening (HTS) plays a pivotal role in drug discovery. It’s used to hunt for ‘hits’ – those sought-after molecules that modulate the activity of targeted biological pathways. Hits can progress through the pipeline to ...

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Could an over-reliance on computational PAINS filters prove a costly mistake for drug discovery?

  High throughput screening (HTS) has long played a vital role in drug discovery within the pharmaceutical industry, and its use in academia is growing too. These large-scale assays are used to screen thousands of compounds in search of hits – those sought after compounds that are used as starting ...

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