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Quality by Design in drug development
Zadeo Cimarosti, 8 September 2017

A more systematic approach to drug development There are few environments where quality control is more important than in drugmanufacturing. Medicines must be safe to use and deliver a consistent clinical effect to treat the targeted disease. However, even with the most robust quality control measures, end-of-line testing cannot improve the...

Adopt a considered screening strategy for your hit identification campaign
Stephan Fasler, 8 September 2017

Developing robust and reliable high-throughput screening assays High-throughput screening (HTS) plays a pivotal role in drug discovery. It’s used to hunt for ‘hits’ – those sought-after molecules that modulate the activity of targeted biological pathways. Hits can progress through the pipeline to lead compounds and potentially, new medicines....

The challenges you must consider when developing a drug for pulmonary delivery
Vince Russell, 8 September 2017

Lung diseases such as asthma, idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) are a growing global healthcare challenge, with figures suggesting they are responsible for around one in ten deaths in the EU. For those developing treatments for these chronic respiratory conditions, pulmonary drug delivery is seen by...

Antibiotic resistance is a global challenge that must be met with a global response
Antonio Felici, 8 September 2017

Antibiotic resistance poses one of the biggest threats to public health in modern times. Currently, an estimated 50,000 deaths across Europe and the US ever year are thought to be caused by antibiotic resistance. If left unchecked, experts believe that resistance to antimicrobial drugs could result in as many as 10 million deaths per year...

Could an over-reliance on computational PAINS filters prove a costly mistake for drug discovery?
Serge Parel, 23 May 2017

  High throughput screening (HTS) has long played a vital role in drug discovery within the pharmaceutical industry, and its use in academia is growing too. These large-scale assays are used to screen thousands of compounds in search of hits – those sought after compounds that are used as starting points in the development of novel...



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