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2017

Translating molecules into medicines: could fresh thinking and collaborative partnerships be the key?
Paul Overton, 1 November 2017

How do we reduce attrition in drug development and ensure scientific innovation translates into safe, effective and affordable treatments for patients? These were the questions at the heart of Aptuit’s one-day think tank event, Improving Candidate Selection Strategies: Translating Molecules into Medicines, held in San Francisco on September...

Drugging the undruggable: how do we put next generation targets within our reach?
Paul Overton, 1 November 2017

What pharmaceutical design strategies must we adopt if we’re to drug the ‘undruggable’ 80% of protein targets thought to be out of reach of current drug discovery techniques? Industry leaders from biotech and pharma gathered at The Marker Hotel, San Francisco, to discuss how to overcome this challenge at Aptuit’s interactive workshop Mission...

New USP and ICH elemental impurities guidelines to drive the production of safer drugs
Mike Cole, 19 October 2017

Heavy metals, also known as elemental impurities, typically exhibit high toxicity if ingested in high quantities. These dangerous substances find their way into drug formulations through manufacturing equipment, container closure systems or raw production materials, while often being used as catalysts in synthesizing the products. It has also...

What's the secret to successful drug formulation?
Mark Saunders, 19 September 2017

Drug formulation plays a vital role in the success of any pharmaceutical development program. From early preclinical investigations through to late stage clinical trials, formulation chemistry is used throughout the development process and is essential for the design of a safe and effective product. Yet, formulation’s importance is often...

Quality by Design in drug development
Zadeo Cimarosti, 8 September 2017

A more systematic approach to drug development There are few environments where quality control is more important than in drugmanufacturing. Medicines must be safe to use and deliver a consistent clinical effect to treat the targeted disease. However, even with the most robust quality control measures, end-of-line testing cannot improve the...

 

 

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