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2017

Translating molecules into medicines: could fresh thinking and collaborative partnerships be the key?
Paul Overton, 1 November 2017

How do we reduce attrition in drug development and ensure scientific innovation translates into safe, effective and affordable treatments for patients? These were the questions at the heart of Aptuit’s one-day think tank event, Improving Candidate Selection Strategies: Translating Molecules into Medicines, held in San Francisco on September...

Drugging the undruggable: how do we put next generation targets within our reach?
Paul Overton, 1 November 2017

What pharmaceutical design strategies must we adopt if we’re to drug the ‘undruggable’ 80% of protein targets thought to be out of reach of current drug discovery techniques? Industry leaders from biotech and pharma gathered at The Marker Hotel, San Francisco, to discuss how to overcome this challenge at Aptuit’s interactive workshop Mission...

New USP and ICH elemental impurities guidelines to drive the production of safer drugs
Mike Cole, 19 October 2017

Heavy metals, also known as elemental impurities, typically exhibit high toxicity if ingested in high quantities. These dangerous substances find their way into drug formulations through manufacturing equipment, container closure systems or raw production materials, while often being used as catalysts in synthesizing the products. It has also...

Drug abuse liability assessment: taking an integrated approach
Maria Pilla, 13 October 2017

There is no questioning the significant benefits prescription drugs can bring to patients’ lives when used appropriately, as per the doctor’s advice. But, that’s not always the case. Prescription medication abuse is a growing challenge affecting the quality of life of millions of people worldwide. This is especially true for drugs capable of...

How to ensure your high throughput screening program is a resource-efficient hit
Serge Parel, 19 September 2017

High throughput screening (HTS) has long been an important first step in the search for new drug molecules. Here, the goal is to identify high-quality hits that can be easily optimized into lead compounds and ultimately, safe and effective medicines. In recent years HTS has become something of a numbers game – after all, with a larger screening...

 

 

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