Insights into all aspects of drug discovery, design and development

New USP and ICH elemental impurities guidelines to drive the production of safer drugs

Heavy metals, also known as elemental impurities, typically exhibit high toxicity if ingested in high quantities. These dangerous substances find their way into drug formulations through manufacturing equipment, container closure systems or raw production materials, while often being used as ...

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Drug abuse liability assessment: taking an integrated approach

There is no questioning the significant benefits prescription drugs can bring to patients’ lives when used appropriately, as per the doctor’s advice. But, that’s not always the case. Prescription medication abuse is a growing challenge affecting the quality of life of millions of people worldwide. ...

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How to ensure your high throughput screening program is a resource-efficient hit

High throughput screening (HTS) has long been an important first step in the search for new drug molecules. Here, the goal is to identify high-quality hits that can be easily optimized into lead compounds and ultimately, safe and effective medicines. In recent years HTS has become something of a ...

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Why Pharma needs a new business model to fight antimicrobial resistance

The ability of bacteria and fungi to develop resistance to antimicrobial treatments isn’t a new phenomenon; we’ve observed the effects since the discovery of the first antibiotics almost a century ago. Antibacterial resistance is an inevitable consequence of natural selection – and it shouldn’t be ...

Topics: Antibiotic Resistance, Antibacterial Read More

What's the secret to successful drug formulation?

Drug formulation plays a vital role in the success of any pharmaceutical development program. From early preclinical investigations through to late stage clinical trials, formulation chemistry is used throughout the development process and is essential for the design of a safe and effective ...

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